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With one exception, meta analyses 68 Banana Republic Womens Madison 12Hour BlockHeel Pump Natural Size 6 H237kqWYQ
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have unanimously confirmed that cholesterol lowering, whether by diet or diet and drugs, decreases CHD risk. The decrease has been estimated to be around 25% for a 10% decrease in cholesterol (equivalent to 0.6 mmol/l on average in the trials), similar to that found in secondary prevention trials, and to the 27% difference observed in two groups of comparable age to those in the trials whose cholesterol differs spontaneously by 10%. 68 Furthermore the 25% decrease in CHD risk was achieved in the trials after the first two years of treatment. There is, however, no evidence from meta analysis for a statistically significant decrease in all cause mortality in primary prevention trials. There has been much speculation about why this should be, but the fact is that CHD deaths in primary prevention trials comprise a much smaller proportion of all deaths compared to secondary prevention. Thus a decrease of 25% or so in CHD death will only have a clear impact on overall mortality if greater numbers of patients are available for meta analysis than have thus far participated in clinical trials, or trials are conducted in higher risk patients. The major reason for asking whether cholesterol lowering decreases all cause mortality is to ensure that it does not increase mortality resulting from some cause other than CHD to a greater extent than it reduces CHD mortality. This question cannot be readily answered with certainty for most medical therapies, including antihypertensive treatment, for which all analyses are currently statistically underpowered. When non-CHD deaths in cholesterol lowering trials are analysed they do not appear to be related to the extent of cholesterol lowering. Sergio Rossi Square hiXDz9cryK
109 The excess of cancer deaths in one diet trial has not been generally encountered in other such trials. Giuseppe Zanotti Neoprene cutout sandal AGNES wJXM5
There does appear to have been a real increase in deaths due to cholelithiasis (or perhaps more accurately cholecystectomy) in the WHO trial of clofibrate, Bianco FAN COUNTER Peeptoe heels raspberry I55k6ErdZr
although now that the intention to treat analysis of this trial is available it is less easy to understand earlier worries about the effect of clofibrate on other causes of death. Gianvito RossiPoint Toe OvertheKnee Boots yqh3q
Nevertheless, the long term follow up of the Helsinki heart study was not entirely reassuring about gemfibrozil and non-CHD deaths. The results of further trials of fibric acid derivatives should, however, help to clarify matters.

Currently, the most reassuring findings about the benefits and safety of lipid lowering treatment in primary prevention come from the WOSCOPS study, the first large primary prevention trial of a statin. 75 In the WOSCOPS study 6595 men aged 45–64 years, with no history of acute MI and whose serum LDL cholesterol was 4.5–6.0 mmol/l despite dietary advice, were randomised to receive pravastatin 40 mg daily. The average serum cholesterol at randomisation was 7.0 mmol/l and the mean serum triglyceride concentration was 1.79 mmol/l. The mean trial observation period was 4.9 years. During this time pravastatin compared with placebo decreased serum cholesterol by 20%, CHD incidence by 31% (p < 0.001), and all cause mortality by 22% (p = 0.051). As in the 4S study, there was no evidence of an increase in non-cardiovascular deaths and the drug compared favourably with placebo in terms of other side effects.

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IMPORTANT: Amazon Complains of “Invisible Characters”

If when you go to publish your book description, and Amazon says “no” and responds with something like “Description may not contain invisible characters” this means that there are some <><> tags that don’t have anything in between the two “<>” and they must be removed before Amazon will be okay.

About a year ago, Amazon made this change. That’s why sometimes when you go to update your KDP dashboard, a book description that you used to have that was acceptable, won’t be now.

So, remove these and your description will be completely fine!

If you had something in the book description generator above, and formatted it, but then deleted it, the Generator will remove the words but won’t remove the formatting tags, thus leaving something like <ul></ul>. Amazon sees the code, but nothing in between them so it calls it invisible code.

Examples of what to look for: BAD:<h2></h2> Good:<h2>These words will be bigger</h2>

BAD: <i></i> GOOD: <i>this phrase is italicized </i>

So, look for where there are some <><> with nothing in between them and remove them and you should be good to go.

Ever wonder why some book descriptions look nicer, have bigger words, and stick out more?

That’s because many self-publishers are using Amazon approved HTML in order to make them look that way. Sounds crazy, right? Well, it turns out that making your description stick out can also help to increase your book’s sales conversion rate…meaning you can get 15% more sales…which is nice.

So, in this article, I will show you two ways in which you can create your own nice looking book description:

There’s the easy way…or the hard way. Either way, your book’s sales page will be popping!

Using the Kindlepreneur Free Book Description Generator

Thanks to the programming side of the Kindlepreneur team, we’ve created a book description generator that anyone can use, without having to know HTML. The above Amazon Book Description Generator will help you to create those beautiful descriptions with just a couple of clicks of a button.

The best part is, even if you know your HTML skills, this tool will allow you to see exactly how it will look before you input it into Amazon. So, no longer do you have to guess, write, publish and then check your page to make sure you didn’t make a mistake or that it looks the way you want it.

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